| Synonyms | Cytosolic inhibitor of Nrf2,INrf 2,INrf2,Keap 1,KEAP1,KEAP1,Kelch like ECH associated protein 1,Kelch like family member 19,Kelch like protein 19,Kelch-like ECH-associated protein 1,Kelch-like protein 19,KIAA0132,KLHL 19,KLHL19,MGC10630,MGC1114,MGC20887,MGC4407,MGC9454 |
| Swissprot | Q14145 |
| Source | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human KEAP1 |
| Application | WB,IHC,ELISA |
| Recommended dilution | WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000 |
| Concentration | 0.8mg/mL |
| Clonality | Polyclonal |
| Cellular localization | Cytoplasm. Nucleus. Shuttles between cytoplasm and nucleus. |
| Isotype | IgG |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | KEAP1,also named as INRF2,KIAA0132 and KLHL19,is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase,which can ubiquitinate the N-terminal domain of NRF2. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2,the ETGE and DLG sites,which affect the KEAP1-NRF2 interaction and/or its physiological consequences. KEAP1 retains NFE2L2/NRF2 in the cytosol. It functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. It also retains BPTF in the cytosol. This antibody is a mouse monoclonal antibody raised against residues near the C terminus of human KEAP1. |
