| Synonyms | CES 1,CES1,Metallothionein 1A,Metallothionein 1S,Metallothionein 2,Metallothionein 2A,Metallothionein IA,Metallothionein II,Metallothionein-1A,Metallothionein-IA,Metallothionein2,MGC32848,MT 1A,MT 2,MT 2A,MT IA,MT II,MT-1A,MT-IA,MT1,MT1A,MT1A,MT1S,MT2,MT2A,MTC |
| Swissprot | P02795 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MT2A |
| Application | WB,IHC,ELISA |
| Recommended dilution | WB 1:1000-1:5000, IHC 1:40-1:200, ELISA 1:5000-1:10000 |
| Concentration | 1.08mg/mL |
| Clonality | Polyclonal |
| Cellular localization | Cytosol,Nucleus,Other locations:cytoplasm,perinuclear region of cytoplasm |
| Isotype | IgG |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. |
