| Synonyms | Annexin 1,Annexin A1,Annexin I (lipocortin I),Annexin I,Annexin-1,AnnexinA1,AnnexinI,ANX 1,ANX A1,ANX1,ANXA 1,ANXA1,ANXA1 protein,ANXA1,Calpactin 2,Calpactin II,Calpactin-2,CalpactinII,Chromobindin 9,Chromobindin-9,Chromobindin9,HGNC:533,Lipocortin 1,Lipocortin I,Lipocortin1,LipocortinI,LPC 1,LPC1,p35,Phospholipase A2 inhibitory protein |
| Swissprot | P04083 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human ANXA1 |
| Application | WB,ELISA |
| Recommended dilution | WB 1:500-1:2000 |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
| Cellular localization | Nucleus. Cytoplasm. Cell projection>cilium. Basolateral cell membrane. Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages. |
| Tissue specificity | Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. |
