| Synonyms | CLM,Cutis laxa with marfanoid phenotype,LAM B1,LAMB 1,LAMB1,LAMB1,Laminin B1,Laminin B1 chain,Laminin beta 1 chain,Laminin beta 1 chain precursor,Laminin beta1,Laminin subunit beta 1,Laminin subunit beta-1,Laminin-1 subunit beta,Laminin-10 subunit beta,Laminin-12 subunit beta,Laminin-2 subunit beta,Laminin-6 subunit beta,Laminin-8 subunit beta,LIS5,MGC142015 |
| Swissprot | P07942,P02469 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | Recombinant protein corresponding to Mouse Laminin β1 |
| Application | WB |
| Recommended dilution | WB 1:500-1:2000 |
| Concentration | 1.2 mg/mL |
| Clonality | Polyclonal |
| Cellular localization | Basement membrane, Extracellular matrix, Secreted |
| Tissue specificity | Highest expression level in lower esophagus |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. |
