| Synonyms | CDKI,CDKN1A-interacting zinc finger protein 1,Cip1-interacting zinc finger protein,CIZ1,CIZ1,cyclin dependent inhibitor 1A,LSFR1,Melanoma differentiation-associated protein,NP94,Nuclear protein NP94,OPHN3,P21,Zinc finger protein 356,ZNF356 |
| Swissprot | P38936 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human P21 protein |
| Application | WB |
| Recommended dilution | WB 1:500-1:1000 |
| Concentration | 2mg/mL |
| Clonality | Polyclonal |
| Cellular localization | Nucleus. |
| Tissue specificity | Expressed in all adult tissues, with 5-fold lower levels observed in the brain.Highest expression level in left coronary artery. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% Proclin300, 50% glycerol, pH7.3. |
| Background | May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). |
