Product information
Product name | Anti-CD31 Antibody （BL-27797） |
Immunogen | Tissue, cells or virus corresponding to Human CD31. |
Host | Mouse |
Reactivity | Mouse, Rat, Human |
Applications | ICC/IF, IHC - Wholemount, WB, IP |
Clonality | Polyclonal |
Isotype | IgG |
Purification | Immunogen affinity purified |
Conjugate | N/A |
Applications
WB | Use a concentration of 1 - 5 µg/ml. |
ICC/IF | 1/100 - 1/1000. |
IHC - Wholemount | 1/100. |
IP | 1/1000. |
ChIP/Chip | N/A |
IHC-P | N/A |
Properties
Formulation | Liquid solution |
Storage buffer | Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative, 1% BSA as stablizer and 50% Glycerol. |
Storage | Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze/ thaw cycle. |
Shipped at 4°C. | Shipped at 4°C. |
Background
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein with a molecular mass of approximately 120-140 kDa. It is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).
