| Reactivity | Application |
| Mouse | WB |
Dilution
WB 1:500-1:2000
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide of human YAP1 (NP_001123617.1). |
| Abbre | YAP1 |
| Synonyms | COB1,YAP,YAP2,YAP65,YKI,YAP1 |
| Swissprot | P46937 |
| Gene ID | 10413 |
| Calculated MW | 36 kDa/48 kDa/49 kDa/50 kDa/52 kDa/53 kDa/54 kDa |
| Observed MW | 72 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density. |
| This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. |
