Tamoxifen ≥99%（BL-49141）
Product information
InChI Key | NKANXQFJJICGDU-QPLCGJKRSA-N |
Assay | ≥99% |
MP | 97-98 °C(lit.) |
Solubility | H2O: insoluble <0.1% at 20 °C |
storage temp. | 2-8°C |
Originator | AstraZeneca |
Gene Information | human ... CYP1A2(1544), EBP(10682), ESR1(2099),ESR2(2100), ESRRA(2101) |
Properties
CAS Number | 10540-29-1 |
Empirical Formula | C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2 |
Molecular Weight | 371.51 |
Beilstein Registry Number | 24900307 |
EC Number | 234-118-0 |
General description
Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.
